Multisystem Inflammatory Syndrome in Children (MIS-C)

Multisystem Inflammatory Syndrome in Children (MIS-C)

Last Updated: August 2021,


Boston Children’s Hospital describes Multisystem inflammatory syndrome in children, MIS-C, (also called pediatric multi-system inflammatory syndrome, PMIS or PIMS), as a newly recognized, potentially serious illness in children that seems to be related to COVID-19. For many children, it appears to be a delayed complication of coronavirus infection, although not all children with MIS-C-related symptoms test positive for the virus. 

MIS-C has varied symptoms that affect several organs and systems in the body. Many children have symptoms resembling toxic shock syndrome or Kawasaki disease, in which blood vessels, including the coronary arteries, enlarge or form aneurysms. Some children have signs of excessive blood clotting, gastrointestinal symptoms, kidney injury, neurologic symptoms, or heart inflammation with impaired heart function. These symptoms can occur in different combinations. 

They tell us that so far, MIS-C seems to be rare, and most children recover with careful observation and treatment. To date, some children with this syndrome have needed to be hospitalized, but only a very small percentage have passed away. 

They recommend consulting with your primary care provider if you think your child has symptoms of MIS-C. Blood tests may be recommended, depending on your child’s symptoms. Children with MIS-C need close observation by pediatric specialists in infectious disease, rheumatology, critical care, and cardiology. (Source


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